Active constituents: Elecampane root and rhizome contain
approximately 1–4% volatile oils.2 Most of these volatile oils are composed
of sesquiterpene lactones, including alantolactone. Elecampane is also very high in inulin
(44%)3 and mucilage. Most herbal texts attribute the actions of elecampane to
alantolactone.4 The antitussive (cough prevention and treatment) and carminative
(soothing effect on the intestinal tract) effects of elecampane, however, may possibly be due
to the inulin and mucilage content. Isolated alantolactone has been used to treat parasites (e.g., roundworm, threadworm, hookworm, whipworm).
This use is only by prescription and is not approved in all European
countries.5
Are there any side effects or interactions? The inulin in
elecampane root is widely distributed in fruits, vegetables and plants. It is classified as a food
ingredient (not as an additive) and is considered safe to eat.8 In fact, inulin is
a significant part of the daily diet of most of the world’s population.9
However, there is a report of a 39-year-old man having a life-threatening allergic reaction
after consuming high amounts of inulin from multiple sources.10 Allergy to inulin
in this individual was confirmed by laboratory tests. Such sensitivities are extremely rare.
Moreover, this man did not take elecampane. Nevertheless, people with a confirmed sensitivity
to inulin should avoid elecampane.
Alantolactone can be an irritant to the intestinal tract and, along with other
sesquiterpene lactones in elecampane, may cause localized irritation in the mouth. Amounts
several times higher than those stated above may cause vomiting, diarrhea, spasms, and signs of paralysis.11 If these
symptoms occur, people should contact their local poison control center. Pregnant or nursing women should not use elecampane.
At the time of writing, there were no well-known drug interactions
with elecampane.
References:
1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients
Used in Food, Drugs, and Cosmetics. New York: John Wiley & Sons, 1996,
222–4.
2. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton,
FL: CRC Press, 1994, 254–6.
3. Duke, JA. Handbook of Phytochemical Constituents of GRAS Herbs and
Other Economic Plants. Boca Raton, FL; CRC Press, 1992.
4. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton,
FL: CRC Press, 1994, 254–6.
5. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide
for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 106–7.
6. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete
German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American
Botanical Council and Boston: Integrative Medicine Communications, 1998, 328–9.
7. Bradley PR (ed). British Herbal Compendium, vol. 1.
Bournemouth, England: British Herbal Medicine Association, 1992, 87–8.
8. Carabin IG, Flamm WG. Evaluation of safety of inulin and oligofructose
as dietary fiber. Regul Toxicol Pharmacol 1999;30:268–82 [review].
9. Coussement PA. Inulin and oligofructose: safe intakes and legal
status. J Nutr 1999;129:1412S–7S [review].
10. Gay-Crosier F, Schreiber G, Hauser C. Anaphylaxis from inulin in
vegetables and processed food. N Engl J Med 2000;342:1372 [letter].
11. Gruenwald J, Brendler T, Jaenicke C, et al. (eds). PDR for Herbal
Medicines. Montvale, NJ: Medical Economics, 1998, 912–3.
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purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
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before making any changes in prescribed medications. Information expires December 2003.