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Non-Nutritive and Artificial Sweeteners
Also indexed as: Acesulfame K, Alitame, Artificial Sweeteners,
Ascesulfame Potassium, Aspartame, Cyclamate, Equal®, NutraSweet®, Saccharin,
Sucralose, Sunette®, Sweet 'N Low®
Today, saccharin, aspartame, sucralose, and acesulfame K are the most
widely used artificial sweeteners.
Non-nutritive sweeteners, also called artificial or non-caloric sweeteners, are intensely
sweet synthetic substances, often used in place of other sugars in food manufacturing and
cooking because they are calorie-free. The United States Food and Drug Administration (FDA)
has approved four non-nutritive sweeteners for use in food: acesulfame K, aspartame,
saccharin, and, sucralose.
Varieties
Acesulfame K
Acesulfame K (Sunette®), or acesulfame potassium, was discovered
in 1967 in Germany. It was approved in 1988 by the FDA as a tabletop sweetener and for use in
baked goods, frozen desserts, beverages, and candies. Consisting of carbon, nitrogen, oxygen,
hydrogen, sulfur, and potassium atoms, acesulfame K is 200 times sweeter than table sugar.
Acesulfame K is not digested, so it contributes no calories to the diet. Some animal studies
suggest a possible cancer-promoting effect.
Aspartame
Aspartame (NutraSweet®) was discovered in 1969, and in 1981 was
approved by the FDA for use in foods. Aspartame is produced from two amino acids—aspartic acid and phenylalanine—and is 180 times sweeter than sucrose.
Although the FDA points to more than 100 scientific experiments that purportedly document the
safety of aspartame, many consumers and scientists are not convinced that long-term daily
intake of aspartame is completely safe, and are concerned about the growing number of foods
that contain this ingredient. Aspartame intake is known to be dangerous for persons with phenylketonuria, a metabolic disorder that results
in dangerously high blood levels of phenylalanine. In addition, aspartame is not recommended
for use by pregnant or lactating women.
Saccharin
Saccharin (Sweet’N Low®) was discovered in 1879, and is
currently produced from a purified compound found in coal tar. Saccharin is 300 times sweeter
than sugar, but has a slightly bitter or metallic aftertaste. It is not metabolized in the
digestive tract and is excreted rapidly in the urine. As a result, saccharin does not
contribute calories to the diet. Three scientific experiments in the early 1970s suggested
that saccharin might be a carcinogen (cancer-causing substance) when given to rats in large
doses. In response, the FDA proposed a ban on saccharin for all uses except as an
over-the-counter drug. Significant public opposition to the FDA ban on saccharin ensued,
prompting the FDA to pass the Saccharin Study and Labeling Act in 1977, which placed a
two-year moratorium on any ban of the sweetener until further research was available. The law
also required that any foods containing saccharin must carry a label that reads, “Use of
this product may be hazardous to your health. This product contains saccharin which has been
determined to cause cancer in laboratory animals.” Most long-term animal studies have
found no cancer-causing effects from saccharin consumption. On December 15, 2000, Congress
passed legislation to remove the warning label that had been required on saccharin-sweetened
foods and beverages since 1977. The National Toxicology Program has removed saccharin from its
list of cancer-causing substances.
Sucralose
Sucralose was discovered in 1976, and has been used as a sweetener in
foods and beverages in more than 30 countries, including Canada, Australia, and Mexico. In
1998, the FDA approved it as a tabletop sweetener and for use in baked goods, beverages,
gelatin, and frozen dairy desserts. In 1999, FDA expanded the approved uses for sucralose,
allowing it as a general-purpose sweetener for all foods. Sucralose is derived from sucrose
(table sugar); it closely resembles table sugar in taste, is highly water-soluble, and is
exceptionally stable at high temperatures. Sucralose is not absorbed from the digestive tract,
so it adds no calories to consumed food. In addition, sucralose does not increase blood sugar
levels.
Equal®
Equal is an artificial sweetener containing aspartame, dextrose, and
maltodextrin.
Alitame
Like aspartame, Alitame is made from amino acids. Alitame is 2,000
times sweeter than sugar. Pfizer, a pharmaceutical company and manufacturer of this sweetener,
petitioned the FDA in 1986 for approval. As of 1992, the approval is still pending.
Cyclamate
Cyclamate was synthesized in 1937 at the University of Illinois by a
student who accidentally discovered its sweet taste. The patent for cyclamate was first
purchased by DuPont and then later sold to Abbott Laboratories. In those days, Abbott’s
reported interest was to use the product to mask the bitter taste of an antibiotic and a
pentobarbital elixir. Cyclamate was initially marketed as tablets that were recommended for
use as a tabletop sweetener for people with diabetes and
others who had to restrict their intake of sugar. Although it is approved for use in many
countries, cyclamate is banned in the United States due to concerns over potential
carcinogenicity.
Buying and storing tips
Saccharin, aspartame, sucralose, and acesulfame K have very long
shelf lives. Store in original packaging in a dry location at room temperature.
Availability
Saccharin is available worldwide as a tabletop sweetener under the
brand name Sweet’N Low®. It is also found in “diet” soft drinks.
Aspartame is available as a tabletop sweetener under the brand name Equal®. It is also
sold as NutraSweet®, an ingredient found in many “diet” beverages and in many
“sugar-free” foods, including chewing gum, cereals, candies, and desserts.
Sucralose is known by its trade name, Splenda®, and is available as a tabletop sweetener
and in many processed foods. Acesulfame K is sold as a tabletop sweetener under the trade name
Sunette®, and appears in a wide variety of processed foods. Alitame and Cyclamate are not
available in the United States.
Preparation, uses, and tips
Non-nutritive sweeteners can be used in place of table sugar to
sweeten hot and cold beverages. In addition, saccharin, sucralose, and acesulfame K are
heat-stable and are suitable for baking. Keep in mind that non-nutritive sweeteners carry more
intense sweetness than sugar. When substituting these products for sugar, only small amounts
are needed to achieve the same level of sweetness. As a result, quantity modifications of
several ingredients in a recipe may be necessary to accommodate the use of saccharin,
sucralose, or acesulfame K.
Nutritional Highlights
Acesulfame K, 1g
Calories: 0.0
Protein: 0.0g
Carbohydrate: 0.0g
Total Fat: 0.0g
Fiber: 0.0g
Aspartame, 1 packet (1g)
Calories: 0.0
Protein: 0.0g
Carbohydrate: less than 1.0g
Total Fat: 0.0g
Fiber: 0.0g
Sucralose, 1 packet (1g)
Calories: 0.0
Protein: 0.0g
Carbohydrate: 0.0g
Total Fat: 0.0g
Fiber: 0.0g
Health benefits and concerns
Hives
Artificial sweeteners (e.g., aspartame) are among the food additives
that have been shown to trigger hives.
Migraine
Ingestion of the artificial sweetener aspartame has been reported to
trigger migraines in a small proportion of people.
MSG sensitivity
People who are sensitive to MSG may also react to aspartame.
Phenylketonuria (PKU)
There is debate about whether it is safe for people with PKU to
consume aspartame, a low-calorie sweetener that contains about 50% phenylalanine. In one study, blood levels of phenylalanine
increased only slightly after people with PKU consumed a 12-oz. soft drink sweetened with
aspartame. However, that study did not address long-term effects of regular aspartame
consumption.
Health benefits and
concerns for sweeteners
Many health benefits and concerns associated with this food are applicable to other
sweeteners. Read about health benefits and concerns
for sweeteners for a full description.
Copyright © 2002 Healthnotes, Inc. All rights
reserved. www.healthnotes.com
Learn more about Healthnotes, the company.
Learn more about the authors of
Foodnotes.
The information presented in Foodnotes is for informational
purposes only and was created by a team of U.S. registered dietitians and food experts.
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using
any supplements, making dietary changes, or before making any changes in prescribed
medications. Information expires December 2003.
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