Also indexed as: Carafate®
Sucralfate is used to treat intestinal ulcers, and it is a type of drug known as a
polysaccharide antipeptic.
Safetychecker Summary
for Sucralfate
(for details about the summarized interactions, read the full article)
 May be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Calcium
Phosphorus
|
| Side effect reduction/prevention |
None known
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
| Adverse interaction |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Calcium
Slight increases in blood calcium levels may occur in people taking sucralfate, which could be
aggravated by calcium supplementation.1 Therefore, people taking calcium
supplements and sucralfate should have their blood calcium levels monitored by their
healthcare practitioner and may need to avoid calcium supplementation.
Phosphorus
People taking sucralfate may develop lower than normal blood levels of phosphorus.2
A 42-year-old woman who took sucralfate for two weeks experienced bone pain that was caused by
low phosphorus levels. The bone pain disappeared after she stopped taking the drug and began
supplementing with phosphorus.3 Individuals taking sucralfate should have their
blood phosphorus levels monitored regularly by their healthcare practitioner and may need to
take supplemental phosphorus.
References:
1. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus,
calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther
Toxicol 1986;24:93–6.
2. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus,
calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther
Toxicol 1986;24:93–6.
3. Chines A, Pacifici R. Antacid and sucralfate-induced hypophosphatemic
osteomalacia: a case report and review of the literature. Calcif Tissue Int
1990;47:291–5.
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Safetychecker.
The information presented in Healthnotes is for informational
purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. Information expires December 2003.
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