Sildenafil is a drug used to treat erectile
dysfunction (ED), commonly known as impotence, in men.
In one study, ingestion of 250 ml (approximately one cup) of grapefruit juice one hour before and together with
sildenafil increased the total amount of sildenafil absorbed by 23%, but tended to delay the
absorption of the drug.1 The authors of this study recommended that sildenafil and
grapefruit juice not be taken together.
Safetychecker Summary
for Sildenafil
(for details about the summarized interactions, read the full article)
 Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
Grapefruit juice
|
| Depletion or interference |
None known
|
| Side effect reduction/prevention |
None known
|
| Supportive interaction |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
References:
1. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. Effects of
grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther
2002;71:21–9.
Copyright © 2002 Healthnotes, Inc. All rights
reserved. www.healthnotes.com
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Safetychecker.
The information presented in Healthnotes is for informational
purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. Information expires December 2003.
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