Glyburide

Also indexed as: Diabeta®, Glibenclamide, Glynase Prestab®, Glynase™, Micronase®, Pres Tab®

Glyburide is a sulfonylurea drug used to lower blood sugar levels in people with type 2 (non-insulin-dependent) diabetes. Maintaining normal blood sugar levels helps reduce health problems associated with diabetes. People with diabetes should consult with their doctor before starting or stopping any form of treatment including drug therapy, herbal products, supplements, and others.

Consumption of a high-fiber diet and/or supplementation with nutrients such as chromium, biotin, vitamin E, and others or herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics. In such cases, the amount of blood sugar-lowering drugs may need to be reduced in order to avoid a hypoglycemic reaction. Anyone taking medication for diabetes should consult the prescribing physician before making dietary changes or taking nutrients or herbs that are designed to lower blood-sugar levels.

Safetychecker Summary for Glyburide
(for details about the summarized interactions, read the full article)

Beneficial May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better.

Aloe vera*
Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Chromium*

Ginkgo biloba
Check Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.

Biotin

Gymnema sylvestre

Vitamin E
Depletion or interference

None known
Side effect reduction/prevention

None known
Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

Aloe (Aloe vera)
One single-blind study in Thailand reported that combining 1 Tbsp (15 ml) of aloe juice twice daily with glyburide significantly improved blood sugar and lipid levels in people with diabetes, compared with placebo.1 Previously, glyburide by itself had not effectively controlled the diabetes in the people in this study.

Ginkgo biloba*
In a preliminary trial, administration of Ginkgo biloba extract (120 mg per day) for three months to patients with type 2 diabetes who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet.2 Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.

Interactions with Foods and Other Compounds

Food
Glyburide may be taken with food to avoid gastrointestinal (GI) upset.3 Effective treatment of type 2 diabetes with glyburide includes adherence to recommended dietary guidelines.

Alcohol
Alcohol consumption may interfere with blood-sugar control during glyburide therapy.4 Alcohol may interact with glyburide, causing facial flushing, headache, light-headedness, nausea, breathlessness, and other symptoms.5 People taking glyburide should avoid alcohol.

References:

1. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996;3:245–8.

2. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol 2001;41:600–11.

3. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.

4. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.

5. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.