Clofibrate

Also indexed as: Atromid-S®

Clofibrate is a drug used to lower cholesterol in people with high blood cholesterol. It is rarely used, due to the possibility of liver damage and the availability of safer, more effective drugs.

Safetychecker Summary for Clofibrate
(for details about the summarized interactions, read the full article)

Beneficial May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.

Vitamin B12*
Beneficial May be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication.

Milk thistle*
Supportive interaction

None known
Reduced drug absorption/bioavailability

None known
Adverse interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

Vitamin B12
Clofibrate has been reported to reduce absorption of vitamin B12.1

Interactions with Herbs

Milk thistle  (Silibum marianum)
Although there have been no clinical studies, use of milk thistle with clofibrate may theoretically lower the risk of liver side effects associated with the drug. People may take a standardized milk thistle extract supplying 70–80% silymarin at an amount of 200 mg three times per day.

References:

1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46–54.