Amiodarone

Safetychecker Summary for Amiodarone
(for details about the summarized interactions, read the full article)

May be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication.	Vitamin E
Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.	Grapefruit juice
Depletion or interference	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known

Interactions with Dietary Supplements

Vitamin E
Test tube research on human lung tissue suggests that vitamin E might reduce lung toxicity caused by amiodarone.¹ More research is needed to further investigate this possibility.

Interactions with Foods and Other Compounds

Grapefruit juice
In one controlled study, drinking grapefruit juice while taking amiodarone dramatically increased blood levels of the drug.² Consequently, people taking amiodarone should avoid drinking grapefruit juice (and eating grapefruit) to prevent potentially serious side effects.

References:

1. Kachel DL, Moyer TP, Martin WJ 2d. Amiodarone-induced injury of human pulmonary artery endothelial cells: Protection by alpha-tocopherol. J Pharmacol Exp Ther 1990;254:1107–12.

2. Libersa CC, Brique SA, Motte KB, et al. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000;49:373–8.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.