Yellow Nail Syndrome

Yellow nail syndrome is believed to be caused by congenital abnormalities in the lymphatic system. Although it primarily affects the nails and lymphatic tissue, it frequently is associated with lung disease.

Checklist for Yellow Nail Syndrome

Rating	Nutritional Supplements	Herbs
	Vitamin E
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

What are the symptoms of yellow nail syndrome? People with yellow nail syndrome may have symptoms including thickened, curved, slow-growing, yellow-to-greenish nails; and swelling of the lymph system in various parts of the body. Additional symptoms relating to the lungs may also occur.

How is it treated? Conventional treatment is directed toward controlling infection in the airway with antibiotics, bronchodilators (medications to open the airways), and physical therapy (e.g., postural drainage, clapping, and vibration). In addition, doctors typically recommend avoiding cigarette smoke and other respiratory irritants, and not using cough suppressants or sleeping pills.

Nutritional supplements that may be helpful: Supplementation with vitamin E has been used successfully with people who have yellow nail syndrome in several preliminary reports.¹ ² ³ Although topical use of the vitamin has also been reported to be effective,⁴ taking vitamin E supplements is much easier and less messy. A typical amount is 800 IU per day, with results beginning to appear after several months.

Are there any side effects or interactions? Refer to the individual supplement for information about any side effects or interactions.

References:

1. Norton L. Further observations on the yellow nail syndrome with therapeutic effects of oral alpha-tocopherol. Cutis 1985;36:457–62.

2. Ayres S Jr, Hihan R. Yellow nail syndrome: response to vitamin E. Arch Dermatol 1973;108:267–8.

3. Ayres S Jr. Yellow nail syndrome controlled by vitamin E therapy. J Am Acad Dermatol 1986;15:714–6 [letter].

4. Williams HC, Buffham R, du Vivier A. Successful use of topical vitamin E solution in the treatment of nail changes in yellow nail syndrome. Arch Dermatol 1991;127:1023–8.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.